Season
- Season 22 2014-09-02
- Season 21 2014-01-06
- Season 20 2013-01-02
- Season 19 2012-01-03
- Season 18 2011-01-03
- Season 17 2009-08-31
- Season 16 2008-09-02
- Season 15 2007-09-04
- Season 14 2006-08-28
- Season 13 2005-08-29
- Season 12 2004-08-23
- Season 11 2003-09-01
- Season 10 2002-09-03
- Season 9 2001-08-20
- Season 8 2000-08-21
- Season 7 1999-09-07
- Season 6 1998-08-31
- Season 5 1997-09-01
- Season 4 1996-09-02
- Season 3 1995-09-04
- Season 2 1994-08-29
- Season 1 1993-08-30
Episode
- Episode 1: Wesley Snipes, Dido
- Episode 2: Jon Favreau, Stone Temple Pilots
- Episode 3: Jack Hanna, Wyclef Jean, Survivor Castaways
- Episode 4: Richard Hatch, Shaquille O'Neal
- Episode 5: Charles Grodin, Donal Logue
- Episode 6: Mary Tyler Moore, Papa Roach
- Episode 7: Ricki Lake, Adam Ferrara
- Episode 8: Rudy Giuliani, Laetitia Casta
- Episode 9: D.L. Hughley, Tony Bennett & Diana Krall
- Episode 10: Tim Robbins, Andy Kindler
- Episode 11: Carson Daly, Dwight Yoakam
- Episode 12: Renee Zellweger, Bonnie Raitt
- Episode 13: Jamie Foxx, Ben Harper and the Innocent Criminals
- Episode 14: Jesse Ventura, Spinal Tap
- Episode 15: Greg Kinnear, Jake Johannsen
- Episode 16: Marat Safin, Sting
- Episode 17: Chris Rock, Emmylou Harris
- Episode 18: Sally Field, Eddie Irvine
- Episode 19: Al Gore, Crosby Stills & Nash
- Episode 20: Kate Hudson, Supergrass
- Episode 21: Sylvester Stallone, Rocco DiSpirito
- Episode 22: Gabriel Byrne, Kevin James
- Episode 23: Denzel Washington, Mark Knopfler
- Episode 24: Ray Romano, Ralph Nader
- Episode 25: Jada Pinkett Smith, LL Cool J
- Episode 26: Geena Davis, Tom Cavanagh
- Episode 27: Christine Baranski, Green Day
- Episode 28: Farrah Fawcett, Loretta Lynn
- Episode 29: Kevin Spacey, Lenny Krayzelberg
- Episode 30: Magic Johnson, Jewel
- Episode 31: Ben Stiller, Merle Haggard
- Episode 32: Regis Philbin, Jim Gaffigan
- Episode 33: Jason Alexander, Anthony Boudain, Foo Fighters
- Episode 34: Martha Stewart, Spike Lee
- Episode 35: Mark Wahlberg, Incubus
- Episode 36: James Caan, Angela Perez Baraquio
- Episode 37: Helen Hunt, Willie Nelson
- Episode 38: Joaquin Phoenix, Allison Moorer
- Episode 39: George W. Bush
- Episode 40: Lawrence Fishburne, Lenny Kravitz
- Episode 41: Will Smith, Derek Jeter
- Episode 42: Show #1500
- Episode 43: Alec Baldwin, Gil de Ferran
- Episode 44: Kathie Lee Gifford, Mark Borchardt
- Episode 45: Madonna
- Episode 46: Don Rickles, Moby & Gwen Stefani
- Episode 47: Adam Sandler, Outkast
- Episode 48: Cokie Roberts, Patricia Arquette
- Episode 49: Lucy Liu, Aaron Neville
- Episode 50: Kid Scientists, Samuel L. Jackson
- Episode 51: Bruce Willis, Charles Barkley
- Episode 52: Mike Myers, Ricky Martin
- Episode 53: Gwyneth Paltrow, Chris Elliot
- Episode 54: Val Kilmer, Everclear
- Episode 55: Susan Sarandon, Kasey Chambers
- Episode 56: Brian Williams, Faith Hill
- Episode 57: Richard Simmons, Giselle Bundchen
- Episode 58: Stupid Human Tricks, Keri Russell
- Episode 59: Matthew Broderick, David Gray
- Episode 60: Bette Midler, Jack Hanna
- Episode 61: Martha Stewart, Christina Aquilera
- Episode 62: Jon Stewart, Everlast
- Episode 63: Mel Gibson, Todd Barry
- Episode 64: Charles Grodin, Bobby LaBonte
- Episode 65: Jay Thomas, Orny Adams
- Episode 66: Helen Hunt, Robert Klein
- Episode 67: CBS Mailbag, At the Drive-In
- Episode 68: Sean Connery, Barenaked Ladies
- Episode 69: Tom Hanks, Darlene Love
- Episode 70: George Clooney, Sade
- Episode 71: Juliette Binoche, Jonathan Witherspoon
- Episode 72: Uma Thurman, Brian Regan
- Episode 73: Lily Tomlin, Anthony Clark
- Episode 74: Jay Mohr, Snoop Dogg
- Episode 75: Benjamin Bratt, Jimmie Walker
- Episode 76: Matt Damon, Fuel
- Episode 77: Sarah Jessica Parker, Jamie Bell
- Episode 78: Tim Robbins, Julie Bowen
- Episode 79: Dennis Quaid, Jason Seahorn
- Episode 80: Kim Cattrall, Bob Sarlatte
- Episode 81: Christine Baranski, Seal
- Episode 82: Dan Rather, Vinnie Jones
- Episode 83: Sean Penn, Lauren Kessler
- Episode 84: Matthew McConaughey, Elle Macpherson
- Episode 85: Neve Campbell, George Miller
- Episode 86: Tom Selleck, Richard Ashcroft
- Episode 87: John Goodman, 3 Doors Down
- Episode 88: Dolly Parton/William Petersen
- Episode 89: Patricia Heaton, Jeff Pobst
- Episode 90: Keanu Reeves, Tony Siragusa
- Episode 91: Jack Black, Aimee Mann
- Episode 92: Anthony Hopkins, Erykah Badu
- Episode 93: Jennifer Lopez, matchbox twenty
- Episode 94: Marv Albert, Katie Holmes
- Episode 95: Regis Philbin, Rod Stewart
- Episode 96: David Boreanaz, Mitch Hedberg
- Episode 97: Kelly Ripa, Jamie Oliver
- Episode 98: Stupid Pet Tricks, Tom Cavanagh
- Episode 99: Chris Rock, Spacehog
- Episode 100: Stephanie Seymour, Nelly
- Episode 101: Megan Mullally, Eddie Brill
- Episode 102: Julia Roberts
- Episode 103: Samuel L. Jackson, Timothy Treadwell
- Episode 104: James Caan, Nelly Furtado
- Episode 105: Benicio Del Toro, Shaggy
- Episode 106: Bill O'Reilly, Jim Gaffigan
- Episode 107: Kevin Pollack, Dave Matthews Band
- Episode 108: Heather Locklear, Allison Krauss, Gillian Welch, Emmylou Harris, The Soggy Bottom Boys
- Episode 109: Tom Brokaw, Leslie Bibb
- Episode 110: Martin Short, Jake Johannsen
- Episode 111: Michael Imperiloli, Josh Joplin Group
- Episode 112: Janet Jackson, Jill Scott
- Episode 113: Denis Leary, Anne Bancroft & Liv Arnesen
- Episode 114: Cokie Roberts, Uncle Kracker
- Episode 115: Antonio Banderas, Nick Cave
- Episode 116: Kristin Davis, Grant Paulsen
- Episode 117: Jerry Seinfeld, Paul Simon
- Episode 118: George Carlin, Powderfinger
- Episode 119: Nathan Lane, Shannon Elizabeth, Cast of The Producers
- Episode 120: Jennifer Love Hewitt, Train
- Episode 121: Johnny Knoxville, The Go-Go's
- Episode 122: Isabella Rossellini, Wendy Lieberman
- Episode 123: Craig Kilborn, Warren Zevon
- Episode 124: Hugh Grant, Sade
- Episode 125: Paul Reubens, Run DMC & Stephan Jenkins
- Episode 126: David Spade, Amanda & Jonny Schwebel
- Episode 127: Carson Daley, Jann Karem, The CBS Giant Orchestra
- Episode 128: Mike Krzyzewski, Semisonic
- Episode 129: Renee Zellweger, Stephen Malkmus
- Episode 130: Holly Hunter, Idlewild
- Episode 131: Tom Green, Dr. Geoffrey Marcy
- Episode 132: LL Cool J, The Living End
- Episode 133: Liv Tyler, Billy Idol
- Episode 134: Billy Crystal, The Bee-Gees
- Episode 135: Don Rickles, Jayson Williams
- Episode 136: Sylvester Stallone, Green Day
- Episode 137: John Goodman, Jeff Stilson
- Episode 138: Kirsten Dunst, Cirque de Soleil
- Episode 139: Matthew Broderick, Brandi Chastain
- Episode 140: Regis Philbin, David Gray
- Episode 141: Bill Murray, Stevie Nicks
- Episode 142: Joan Cusack, Andy Kindler
- Episode 143: Tina Wesson, Kate Hudson, The Blind Boys of Alabama
- Episode 144: Uma Thurman, Blues Traveler
- Episode 145: Kid Scientists, Juliette Lewis
- Episode 146: Jenna Elfman, Destiny's Child
- Episode 147: Heath Ledger, Lewis Black
- Episode 148: Charlie Sheen, Missy Elliot
- Episode 149: John Travolta, R.E.M.
- Episode 150: Mike Myers, David Byrne
- Episode 151: Andrea Noceti, Jack Hannah, Ricky Martin
- Episode 152: Kelsey Grammar, Smothers Brothers
- Episode 153: Ray Romano, Dennis Tito
- Episode 154: Stupid Human Tricks, Ellen DeGeneres
- Episode 155: Alec Baldwin, Yogi Berra
- Episode 156: Tom Brokaw, Badly Drawn Boy
- Episode 157: Danny DeVito, Larry Miller
- Episode 158: Helio Castroneves, Tom Dreesen, Lucinda Williams
- Episode 159: David Duchovny, Trisha Yearwood
- Episode 160: Jimmy Fallon, The Black Crowes
- Episode 161: Dan Rather, Elvis Costello & Anne Sofie von Otter
- Episode 162: Andy Dick, Brian Regan
- Episode 163: Marv Albert, Sugar Ray
- Episode 164: Luke Perry, Jim White
- Episode 165: Kim Cattrell, Mary Chapin Carpenter
- Episode 166: Star Jones, blink-182
- Episode 167: Jon Stewart, David Brenner
- Episode 168: Dikenbe Mutombo, David Bowley, Cesaria Evora
- Episode 169: Tom Arnold, David Sedaris
- Episode 170: Jimmy Kimmel, PJ Harvey
- Episode 171: Ewan McGregor, Moby
- Episode 172: Chris Elliot, Harry Hill
- Episode 173: John McCain, Shawn Wayans
- Episode 174: Catherine Zeta-Jones, Depeche Mode
- Episode 175: Marlon Wayans, Alan Webb, Coldplay
- Episode 176: Sean Hayes, Brian Wilson, Darrius Rucker, Matthew Sweet
- Episode 177: Tony Danza, Nick DiPaolo
- Episode 178: Reese Witherspoon, Jonatha Brooke
- Episode 179: Julia Roberts, Travis
- Episode 180: Edward Norton, Dido
- Episode 181: Juliana Marguiles, George Miller
- Episode 182: Vince Vaughn, Elayne Boosler
- Episode 183: Piedmont Bird Callers, Hank Azaria, Maria McKee
- Episode 184: Kelly Ripa, Bob Sarlotte
- Episode 185: John McEnroe, Youssou N'Dour
- Episode 186: Jon Favreau, The Holmes Brothers
- Episode 187: Billy Crystal, Al Lubel
- Episode 188: Jeff Meyer, Christopher Walken, Widespread Panic
- Episode 189: Tom Selleck, David Rakoff
- Episode 190: Mark Wahlberg, Michael Lomonaco, Tegan & Sara
- Episode 191: Greg Kinnear, Afro Celt Sound System & Peter Gabriel
- Episode 192: Marilu Henner, Hugh Fink
- Episode 193: Kristin Davis, Nanci Griffith, Mark Borschardt
- Episode 194: Sean Combs
- Episode 195: Lance Armstrong, Thora Birch, Jamie O'Neal
- Episode 196: Nicole Kidman, Iggy Pop
- Episode 197: Antonio Banderas, Jeffrey Ross
Late Show with David Letterman Season 8 Will Smith, Derek Jeter
David Letterman uses mature humor to appeal to his audience in this weeknight series, which gets its music from a house band led by Paul Shaffer. Among the show's most-famous segments are the Top Ten List and Stupid Pet Tricks, the latter of which subsequently led to an additional recurring segment called Stupid Human Tricks.
