Season
- Season 22 2014-09-02
- Season 21 2014-01-06
- Season 20 2013-01-02
- Season 19 2012-01-03
- Season 18 2011-01-03
- Season 17 2009-08-31
- Season 16 2008-09-02
- Season 15 2007-09-04
- Season 14 2006-08-28
- Season 13 2005-08-29
- Season 12 2004-08-23
- Season 11 2003-09-01
- Season 10 2002-09-03
- Season 9 2001-08-20
- Season 8 2000-08-21
- Season 7 1999-09-07
- Season 6 1998-08-31
- Season 5 1997-09-01
- Season 4 1996-09-02
- Season 3 1995-09-04
- Season 2 1994-08-29
- Season 1 1993-08-30
Episode
- Episode 1: Bill Murray, Tom Brokaw, Paul Newman, Billy Joel
- Episode 2: Robin Williams, John Mellencamp, Jonathan Estrata
- Episode 3: Demi Moore, Bev Tanner, Spin Doctors
- Episode 4: Martin Short, Cyndi Lauper
- Episode 5: Debra Winger, Soul Asylum
- Episode 6: Richard Lewis, Shawn Bouroughs, Midnight Oil
- Episode 7: Michael J. Fox, Rosie Perez
- Episode 8: Al Gore, Kim Basinger, Chris Isaak
- Episode 9: Ellen Barkin, Chris "Mad Dog" Russo, Lenny Kravitz
- Episode 10: Siskel & Ebert, Robert Plant
- Episode 11: Bruce Willis, Steven Wright
- Episode 12: Paul Reiser, Mike Ditka, John Hiatt
- Episode 13: Jeff Goldblum, Louie Anderson, Jerry Garcia & David Grisman
- Episode 14: Bonnie Hunt, Latrisha Baldrick, Patti Smyth
- Episode 15: Super Dave Osborne, Laura Dern, Stone Temple Pilots
- Episode 16: Sarah Jessica Parker, Jim Abbot, Patty Scialfa
- Episode 17: Robert Urich, Ellen Degeneres, Tim Tomasic
- Episode 18: Tony Randall, Elizabeth Perkins, Aaron Neville
- Episode 19: Mike Myers, John Kruk, Belinda Carlisle
- Episode 20: Glenn Close, James Taylor
- Episode 21: Matthew Broderick, Julie Krone, Neil Diamond
- Episode 22: Jimmy Carter, Brett Butler, Daniel Boulud
- Episode 23: Jerry Lewis, Sparky Mortimer, Rod Stewart
- Episode 24: Lily Tomlin, Adam Sandler, Mike Lupica
- Episode 25: Andie MacDowell, Graham Parker, Bill Scheft
- Episode 26: Sylvester Stallone, Melissa Etheridge, Janeane Garofalo
- Episode 27: Isabella Rossellini, Bob Saget, Johnny Cash
- Episode 28: Candice Bergen, John Mendoza
- Episode 29: Don Rickles, Tracey Ullman, Johnny Cash
- Episode 30: Connie Chung, Mary Chapin Carpenter
- Episode 31: Kathie Lee Gifford, Matt Dillon
- Episode 32: Stupid Pet Tricks, Howard Stern, Rosanne Cash
- Episode 33: Kirstie Alley, Rick Ocasek, Jeff Colton
- Episode 34: David Brenner, Gloria Estefan, Sean Young
- Episode 35: Tom Arnold, Rich Hall, Jon Weiss
- Episode 36: Dennis Miller, Tony Bennett, Sandra Bullock
- Episode 37: David Steinberg, Emmylou Harris, Bo Jackson
- Episode 38: Dan Rather, Penelope Ann Miller, Gin Blossoms
- Episode 39: Bob Newhart, Guru, Chloe Disker
- Episode 40: Martin Mull, The Pogues, Jean Louie
- Episode 41: Sean Connery, Jake Johannsen, Fran Drescher
- Episode 42: Phil Donahue, Art Garfunkel, Lenny Dykstra, Paul Molitor
- Episode 43: Marv Albert, Cindy Crawford, Natalie Cole
- Episode 44: George Foreman, INXS & Ray Charles
- Episode 45: Martin Lawrence, Phil Collins
- Episode 46: Jay Thomas, Squeeze, Martha Stewart
- Episode 47: Terry Garr, Paul Simon
- Episode 48: Mike Wallace, Jimmy Cliff, Faith Ford
- Episode 49: Annie Potts, Natalie Merchant, Dorothy Nash
- Episode 50: Tony Curtis, The Breeders, Calvin Trillian
- Episode 51: Michael Keaton, Barbara Walters
- Episode 52: Evander Holyfield, Phil Hartman, The BoDeans
- Episode 53: Mary Tyler Moore, Jackson Browne, Rita Rudner
- Episode 54: Tom Selleck, Pete Townsend
- Episode 55: Barry Bonds, Carol Kane, Living Colour
- Episode 56: Sinbad, Trisha Yearwood, Charlie Sheen
- Episode 57: Billy Crystal, Los Lobos
- Episode 58: Stupid Human Tricks, Jon Lovitz, George Thoroughgood
- Episode 59: Billy Connolly, Bob Dylan, Charles Kuralt
- Episode 60: Dana Carvey, Meatloaf, Joan Cusak
- Episode 61: Marilu Henner, Heart, Father Guido Sarducci
- Episode 62: Robert Klein, Cowboy Junkies, Bobby Knight
- Episode 63: Bryant Gumbel, Taylor Dayne, Dave Attel
- Episode 64: Penn & Teller, Dwight Yoakam, Gabriel Byrne
- Episode 65: Kelsey Grammar, Patrick Ewing, Warren Zevon
- Episode 66: James Belushi, Carlene Carter, Lauren Holley
- Episode 67: Robin Williams, Larry Johnson
- Episode 68: Sam Donaldson, Mike Myers, Nanci Griffith
- Episode 69: Jeremy Irons, Bruce Hornsby
- Episode 70: Charles Grodin, Bryan Adams, Jack Hannah
- Episode 71: Sally Field, Carly Simon, Robert Duvall
- Episode 72: Larry King, The Band, Kevin Pollack
- Episode 73: Luciano Pavarotti, Marisa Tomei, Wayne Cotter
- Episode 74: Tom Hanks, Gipsy Kings, Joan Plowright
- Episode 75: Rush Limbaugh, Harry Connick Jr.
- Episode 76: Whoopi Goldberg, Clint Black, John Witherspoon
- Episode 77: Will Smith, The Lemonheads, Emmit Smith
- Episode 78: Bob Costas, Toni Braxton, Debi Mazar
- Episode 79: Dennis Franz, Mike Judge, Andy Williams
- Episode 80: Joan Lunden, Ian Moore, Wendy Wasserstein
- Episode 81: Jason Priestly, Terry Bradshaw, Norm MacDonald
- Episode 82: Bonnie Hunt, Tony Toni Tone, Dennis Rogers
- Episode 83: Julia Roberts, Cracker, Wolfgang Puck
- Episode 84: Rosanne and Tom Arnold, Jon Bon Jovi
- Episode 85: Jane Pauley, Art Donavan
- Episode 86: Beau Bridges, Sandra Bernhard, 4 Non Blondes
- Episode 87: Rosie O'Donnell, Lou Reed, Neil Patrick Harris
- Episode 88: Chris Elliot, Itzhak Perlman, Cokie Roberts
- Episode 89: Martin Mull, Drew Carey, Dana Delany
- Episode 90: Rudolph Giuliani, Faith Hill, Ricki Lake
- Episode 91: Troy Aikman, Marilyn Horne, Jon Stewart
- Episode 92: Smothers Brothers, Indigo Girls, Sara McClendan
- Episode 93: George Carlin, Urge Overkill, Jan Hooks
- Episode 94: Chevy Chase, George Miller, Halle Berry
- Episode 95: Richard Harris, Taj Mahal & Etta James, David Spade
- Episode 96: David Brenner, Travis Tritt, Madeline Stowe
- Episode 97: Kathie Lee Gifford, Aaron Neville, Bruno Kirby
- Episode 98: Demi Moore, Willie Nelson & Shelby Lynne, Al Franken
- Episode 99: Dan Rather, Dave Pirner & Victoria Williams, Brett Hull
- Episode 100: Jimmy Johnson, Martin Lawrence, Concrete Blonde
- Episode 101: Tom Brokaw, Julie Cavner, Joshua Catheson
- Episode 102: Aidan Quinn, Crowded House, Michael Lamonaco
- Episode 103: Sarah Jessica Parker, Jerry Van Dyke
- Episode 104: Ellen Barkin, Peter Frampton, Amanda Archaleta
- Episode 105: Walter Cronkite, Natalie Merchant
- Episode 106: Alec Baldwin, Blues Traveler, Norman Vaughn
- Episode 107: Dan Aykroyd, Anna Klempsey, Peter Arnette
- Episode 108: Siskel & Ebert, Daryl Hall, Muggsy Bogues
- Episode 109: Steven Seagal, Salt N Peppa, Johnathan Soloman
- Episode 110: Super Dave Osborne, Brad Privott
- Episode 111: Richard Simmons
- Episode 112: Regis Philbin, Richard Thompson, Ben Stiller
- Episode 113: Phil Hartman, George Benson, Michael Madsen
- Episode 114: Bebe Neuwirth, Jackson Browne
- Episode 115: Sinbad, UB40, Luke Perry
- Episode 116: Marv Albert, Sinead O'Connor, Ricky Jay
- Episode 117: Stupid Human Tricks, Wynonna Judd, Laurence Fishburne
- Episode 118: Brett Butler, Linda Rondstat, Don Imus
- Episode 119: Michael J. Fox, Spin Doctors & Roger Daltrey
- Episode 120: Gary Shandling, Sting, Nigel Mansell
- Episode 121: Dan Jansen, Dennis Miller, Meatloaf
- Episode 122: John Larroquette, Bonnie Raitt, Jerry Butler, & Ben E. King, Jennifer Jason Leigh
- Episode 123: Geena Davis, Aerosmith
- Episode 124: Anthony Hopkins, ZZ Top, Dennis Leary
- Episode 125: Alan King, Aretha Franklin
- Episode 126: Jay Thomas, Crash Test Dummies, Kevin Spacey
- Episode 127: Richard Harris, Carol King, Ron Howard
- Episode 128: Bill Cosby, Sheryl Crow
- Episode 129: Diane Sawyer, John Michael Montgomery, Elle MacPherson
- Episode 130: Kevin Kline, Placido Domingo
- Episode 131: Bob Saget, Tori Amos, John Waters
- Episode 132: Thea Vidal, Stomp, Buck Henry
- Episode 133: Martin Short, Sammy Hagar, Mary Stuart Masterson
- Episode 134: Madonna, Counting Crows
- Episode 135: Charles Grodin, Elvis Costello & The Attractions
- Episode 136: Bob Uecker, Cheap Trick, Michael McKean
- Episode 137: Ted Koppel, Wynton Marsalis, Carrie Fisher
- Episode 138: Andie MacDowell, Rich Hall, Matt Kramer
- Episode 139: Kirstie Alley, Boz Scaggs, Calvin Trillian
- Episode 140: Tom Brokaw, Blind Melon, Julie Brown
- Episode 141: Don Rickles, Jeff Stearns, Liz Phair
- Episode 142: Jack Lemmon, Lyle Lovett & Al Green
- Episode 143: Dennis Hopper, Jessye Norman, Uta Pippig
- Episode 144: Ellen DeGeneres, Raquel Welch, Candlebox
- Episode 145: Tom Snyder, Ray Liotta
- Episode 146: Father Guido Sarducci, Reba McEntire, Pierre Frene
- Episode 147: Joan Lunden, Gin Blossoms, Michael Moore
- Episode 148: Jerry Seinfeld, Brian Setzer Orchestra, Norm Abram
- Episode 149: Sissy Spacek, Bonnie Raitt, Daniel Low
- Episode 150: Joe Pesci, Randy Travis, Dan Wilkinson
- Episode 151: Jerry Van Dyke, The Neville Brothers
- Episode 152: Robin Williams, Big Head Todd & The Monsters, Mark Leyner
- Episode 153: Mia Farrow, Tim McGraw, Jimmie Walker
- Episode 154: Brett Butler, Rob Lowe, Sarah McLachlan
- Episode 155: Sharon Stone, Chris Farley
- Episode 156: Billy Crystal, Ray Charles
- Episode 157: Michael Keaton, Angela Lansbury
- Episode 158: James Cahn, David Copperfield, Julia Louis-Dreyfus
- Episode 159: Candice Bergen, Elvis Costello & The Attractions, Magic Johnson
- Episode 160: Bette Midler, Traffic
- Episode 161: Heather Locklear, Travis Tritt, Harvey Pekar
- Episode 162: Jeff Goldblum, Sonic Youth, James Carville
- Episode 163: Stupid Pet Tricks, Carol Burnett, Emmylou Harris
- Episode 164: Barbara Walters, Mariah Carey
- Episode 165: Eddie Murphy, Tony Bennett, Wayne Cotter
- Episode 166: Rick Moranis, Jimmy Buffett, Stefan Seville
- Episode 167: Woody Harrelson, Louie Anderson, Isaiah Thomas
- Episode 168: Kevin Pollak, Chris Isaak, Jacques Pepin
- Episode 169: Rosie O'Donnell, Laurie Morgan, Bronson Pinchot
- Episode 170: The Pretenders, Daniel Stern
- Episode 171: Reggie Miller, Spike Lee, Tony Randall, Tony Toni Tone
- Episode 172: Craig T. Nelson, David Sanborn, Al Unser Jr.
- Episode 173: Mariel Hemmingway, George Miller, Mandy Patinkin
- Episode 174: Macaulay Culkin, Randy Newman, Mona Frey
- Episode 175: David Brenner, Johnny Cash, Keanu Reeves
- Episode 176: Jeremy Irons, Chris Rock, Hakeem Olajuwon
- Episode 177: Ted Danson, David Byrne, Carl Reiner
- Episode 178: Show #0178
- Episode 179: Jon Lovitz, Sandra Bullock, Spin Doctors
- Episode 180: Teri Garr, Yes
- Episode 181: Fran Drescher, Jack Palance, Seal
- Episode 182: Dan Rather, Nicholas Turturro, Al Jarreau, Kathleen Battle
- Episode 183: Julia Roberts, Stone Temple Pilots, Jake Johannsen
- Episode 184: Howard Stern, Kate Nelligan, John Mellencamp
- Episode 185: Siskel & Ebert, Tom Jones, Sam Cassell, Trisha Yearwood
- Episode 186: Penelope Ann Miller, Barbara Streisand, Mary Matalin, Tori Amos
- Episode 187: Daniel Boulud, Helen Hunt, Green Day
- Episode 188: Siskel & Ebert, Andrea Martin, Indigo Girls
- Episode 189: Connie Chung, Phil Collins
- Episode 190: Neil Diamond, Richard Simmons
- Episode 191: Patrick Stewart, Ryan Cobb, Melissa Etheridge
- Episode 192: Show #0192
- Episode 193: Tom Hanks, Toad the Wet Sprocket
- Episode 194: Harry Connick, Jr., Michael Lomonaco, Pete Sampras, Catherine O'Hara
- Episode 195: Buzz Aldrin, Susan Sarandon, Midnight Oil
- Episode 196: Gary Sinise, Ricki Lake, Julio Iglesias
- Episode 197: Show #0197
- Episode 198: Show #0198
- Episode 199: Show #0199
- Episode 200: Show #0200
- Episode 201: Show #0201
- Episode 202: Show #0202
- Episode 203: Show #0203
- Episode 204: Show #0204
- Episode 205: Show #0205
- Episode 206: Show #0206
- Episode 207: Show #0207
- Episode 208: Show #0208
- Episode 209: Show #0209
- Episode 210: Show #0210
- Episode 211: Show #0211
- Episode 212: Show #0212
- Episode 213: Show #0213
- Episode 214: Show #0214
- Episode 215: Show #0215
- Episode 216: Show #0216
- Episode 217: Show #0217
- Episode 218: Show #0218
- Episode 219: Show #0219
Late Show with David Letterman Season 1 Kathie Lee Gifford, Matt Dillon
David Letterman uses mature humor to appeal to his audience in this weeknight series, which gets its music from a house band led by Paul Shaffer. Among the show's most-famous segments are the Top Ten List and Stupid Pet Tricks, the latter of which subsequently led to an additional recurring segment called Stupid Human Tricks.
